From the digestive system: nausea, vomiting, diarrhea, loss of appetite, erosive gastritis, pseudomembranous colitis; increased activity of “liver” transaminases, alkaline phosphatase, serum hyperbilirubinemia, hepatitis, acute pancreatitis.
Cardio-vascular system: thrombocytopenic laisa andriol purpura, thrombocytopenia and leukopenia, bleeding, acute hemolytic anemia.
On the part of the central nervous system: headache, blurred vision, ataxia, disorientation.
From the urinary system: nefronekroz, interstitial nephritis.
Allergic reactions: rash, eosinophilia, angioedema, bronchospasm, arthralgia, fever.
Other: leukopenia, dysmenorrhea, induction of porphyria, myasthenia gravis, hyperuricemia, gout exacerbation.
At irregular admission or resuming treatment after a hiatus may be flu-like symptoms (fever, chills, headache, dizziness, myalgia), skin reactions, hemolytic anemia, thrombocytopenic purpura, acute renal failure.
If any of these instructions side effects are compounded, or observed any other side effects not mentioned in the instructions, you should immediately inform your doctor.
Symptoms: nausea, laisa andriol vomiting, abdominal pain, enlarged liver, jaundice, periorbital edema, or swelling of lime, “red man syndrome” (krasnooranzhevoe staining of the skin, mucous membranes and sclera), “pulmonary edema, lethargy, confusion, convulsions.
Treatment: symptomatic; gastric lavage, activated charcoal; forced diuresis.
Interaction with other drugs
It reduces activity of indirect anticoagulants, oral hypoglycemic drugs, hormonal contraceptives, cardiac glycosides, antiarrhythmic drugs (disopyramide, pirmenol, quinidine, mexiletine, tocainide), corticosteroids, dapsone, phenytoin, hexobarbital, nortriptyline, benzodiazepines, theophylline, chloramphenicol, ketoconazole, itraconazole , cyclosporine, azathioprine, beta-blockers, calcium channel blockers slow, enalapril, cimetidine (rifampicin causes induction of cytochrome P450 isoenzymes, accelerating their metabolism)
Co-trimoxazole (sulfamethoxazole + trimethoprim) increases the concentration of rifampicin in the blood. In an application rifampntsina (600 mg / day), ritonavir (100 mg 2 times a day) and saquinavir (1000 mg), can develop severe hepatotoxicity. When used together rifampicin significantly reduces plasma concentrations atazanavir, darunavir, fosamprenavir, tipranavir, saquinavir, and that can reduce the antiviral activity.
Rifampicin accelerates metabolism of certain tricyclic antidepressants, lipid-lowering drugs (simvastatin, etc.), Antimalarials (mefloquine, etc..), Cytotoxic drugs (tamoxifen, etc.).
Antacids, narcotic analgesics, anticholinergic drugs and reduce ketoconazole (in case of simultaneous oral) bioavailability of rifampicin.
Isoniazid laisa andriol pyrazinamide increased incidence and severity of liver dysfunction in more than one appointment rifampicin in patients with previous liver disease.
Preparations of sodium para-aminosalicylate should be administered no earlier than 4 hours after taking the drug because possible violation of absorption
In pregnancy, the drug is prescribed only for “real life” testimony.
Women of childbearing age during treatment should use reliable methods of contraception (oral hormonal contraceptives and additional non-hormonal methods of contraception). Possible false-positive result in the immunological determination of opiates in urine. It should be noted that rifampicin interacts with contrast drugs used during holetsistografii. Under its influence may distort the results of X-ray studies.
The treatment of the skin, mucus, sweat, feces, lacrimal fluid, urine acquire oranzhevokrasny color. Can bravely painted soft contact lenses.
To prevent the laisa andriol development of microbial resistance need to be used in combination with other antimicrobial drugs.
In the case of flu-like syndrome, not complicated by thrombocytopenia, hemolytic anemia, bronchospasm, dyspnea, shock and renal failure in patients receiving medication for intermittent scheme, you should consider switching to a daily intake. In these cases, the dosage is increased slowly for the first day administered 75-150 mg, and the desired therapeutic dose is achieved in 3-4 days. If serious complications noted above, rifampicin overturned. It is necessary to monitor kidney function; possible further appointment of glucocorticosteroids.
In the case of prophylactic use of bacilli carrier from meningococcal requires strict monitoring of patients in order to quickly identify the symptoms of the disease in the event of resistance to rifamnitsinu.
With prolonged use is shown systematically monitor patterns of peripheral blood and liver function. In the period of treatment can not be used microbiological methods for determining the concentration of folic acid and vitamin B12 in the blood serum. If signs of toxic hepatitis drug overturned.
Information on the possible impact of the drug for medical use on the ability to drive vehicles, machinery
drug can laisa andriol cause headache and decreased visual acuity, need to be careful in the management of transport, when working with machinery.