A few years after treatment dr gerald andriole in the treatment of dyskeratosis a total course dose and duration of therapy, above recommended for the treatment of acne, developed bone changes including premature closure of epiphyseal growth zones, hyperostosis, calcification of ligaments and tendons. Therefore, the appointment of the drug to any patient, you should first carefully weigh the potential benefits and risks.
Patients receiving , it is recommended to use a moisturizing cream or body lotion, lip balm to reduce the dryness of the skin and mucous membranes at the beginning of therapy.
During post-marketing surveillance with the use described cases of severe skin reactions such as erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.These effects can be serious and lead to potere disability, life-threatening, or fatal hospitalization. Patients receiving , need to be closely monitored in order to detect severe skin reactions and the need to address the issue of elimination of the drug.
In patients receiving may be pain in muscles and joints, increased serum activity, which may be accompanied by a reduction in tolerability intensive physical exertion.
avoid carrying out deep dermoabrazii chemical and laser treatment in patients receiving , as well as within 5-6 months after treatment because of the potential power of scarring in atypical areas and (less frequently) occurrence of hyper- and hypopigmentation. During treatment withdr gerald andriole , and for 6 months after it is impossible to carry out hair removal using the applications of wax due to the risk of detachment of the epidermis, the development of scarring and dermatitis.
Because some patients may experience reduced visual twilight vision, which is sometimes retained after the end of therapy , patients should be informed about the possibility of this condition, encouraging them to use caution when driving at night. Status of visual acuity should be carefully monitored.
Dry eye conjunctiva, corneal opacities, deterioration of twilight vision and keratitis usually disappear after discontinuation of the drug. When mucosal dryness of the eyes, you can use applications moisturizing eye ointment or preparation of artificial tears. It should be observed in patients with dryness of the conjunctiva for the possible development of keratitis. Patients complain of vision, should be sent to the ophthalmologist and consider whether to cancel the drug . At intolerance of contact lenses at the time of treatment should be used glasses.
It is to limit exposure to the sun and ultraviolet rays. If necessary, use a sunscreen with a high protection factor of at least 15 SPF (sun protection factor).
Described rare cases of benign intracranial hypertension ( “brain pseudotumor”), including: the combined use with tetracyclines. These patients should be discontinued immediately .
When therapy with dr gerald andriole may cause inflammatory bowel disease. In patients with severe hemorrhagic diarrhea should be abolished immediately .
Described rare cases of anaphylactic reactions that occurred only after previous topical retinoids. Severe allergic reactions necessitate discontinuation of therapy and careful monitoring of the patient.
Patients at high risk (with diabetes, obesity, alcoholism or disorders of lipid metabolism) in the treatment of drug Roaccutane ® may require more frequent laboratory monitoring of glucose and lipids.
In the presence of diabetes or suspected, it is recommended more frequent blood glucose determination.
Contact medicines into the environment should be minimized. Do not dispose of the drug via wastewater or with household waste. If possible, a special system for the disposal of drugs should be used.
Effects on ability to drive vehicles and working with machines and mechanisms
In treatment it is necessary to exercise extreme caution when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Because some patients may experience reduced visual dr gerald andriole twilight vision, which sometimes persists after the end of therapy, patients should be informed about the possibility of this condition, encouraging them to use caution when driving and working with machines and mechanisms at night.