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Time to reach maximum concentration of 2 – 4 h. The apparent volume of distribution – 0.41 l / kg and the volume is equal to the distribution of water in the body.  It is metabolized by cytochrome buy andriol testocaps system to hydroxylated inactive metabolites with subsequent glucuronidation.The major isozymes responsible for metabolism. Ritonavir is an inhibitor of isoenzymes. Smoking, body weight, age, sex, CYP2D6-phenotype does not affect the clearance of the drug. The half-life in children 2 – 14 1.5 times shorter than that of adults, at the same time the maximum concentration  are identical. Repeated reception of the same Cmin dose, area under the concentration – time and  are reduced. Displayed through the intestine (20 – 40% unchanged).

INDICATIONS
HIV infection in adults and children (in a combination therapy).

CONTRAINDICATIONS

  • established hypersensitivity to ritonavir or one of the formulation components;
  • severe hepatic impairment;
  • children’s age (up to 2 years);
  • concomitant use of these drugs – amiodarone, astemizole, bepridil, cisapride, dihydroergotamine, ergotamine, encainide, flecainide, pimozide, propafenone, quinidine and terfenadine, midazolam, triazolam.

Pregnancy and lactation
The use of ritonavir during pregnancy, breast-feeding is possible when the expected benefit to the mother outweighs the potential risk to the fetus. Women should not breast-feed your children under any circumstances to avoid transmission.

SIDE EFFECTS
The most frequently observed in patients fatigue, gastrointestinal and neurological disorders.

Side effects from the organs and systems:

Nervous system: dizziness, buy andriol testocaps headache, migraine, paresthesia, hyperesthesia, somnolence, insomnia, bad dreams, amnesia, aphasia, ataxia, epilepsy, impaired coordination, neuralgia, neuropathy, paralysis, distortion of the sense of smell, peripheral neuropathy, peripheral sensory neuropathy, taste loss , tremor, disturbance of the visual field.

Psychiatric disorders: anxiety, confusion, depression, emotional lability, euphoria, hallucinations, decreased libido, nervousness, personality disorder, unpleasant thoughts.

Hearing and labyrinth disorders: ear pain, hearing loss, an increase in the secretion of sulfur, tinnitus.

Visual disturbances: blurred vision, amblyopia / blurred vision, blepharitis, diplopia, eye pain, inflammation of the iris, photophobia, uveitis.

Cardiovascular: vasodilation, palpitations, fainting, hemorrhage, hypotension, orthostatic hypotension, peripheral circulatory disorder, tachycardia.

The circulatory system and blood: anemia, bruising, radiation, lymph lymphadenopathy, lymphocytosis, thrombocytopenia.

Respiratory system: sore throat, dry cough, bronchospasm, dyspnea, epistaxis, hiccup, hypoventilation, lung function, interstitial pneumonia, rhinitis.

Digestive system: abdominal pain, dyspepsia, nausea, diarrhea, vomiting, lack of appetite, taste disturbance, flatulence, belching, dry mouth, ulceration of the mouth, perioral and peripheral paresthesia, abdominal enlargement, stool disorders, bloody stools, cheilitis, colitis , constipation, dysphagia, esophagitis, gastritis, gastroenteritis, gastrointestinal hemorrhage, buy andriol testocaps gingivitis, ileitis, candidiasis of the oral mucosa, pancreatitis, periodontal abscess, tenesmus, thirst. steroids symptoms tritest 400 steroids for sale