andriol testocaps

Risperidone safety in pregnant women has not been studied. When pregnancy only be used if a positive effect justifies the potential risk.

Since risperidone andriol testocaps and 9-hydroxyrisperidone into breast milk, women using the drug should not breast-feed.

Dosing and Administration

Schizophrenia. Adults and children over 15 years. Risdonal can be administered once or twice a day. Initial dose – 2 mg per day. On the second day, the dose should be increased to 4 mg per day. From this point the dose can either maintain the same level, either individually adjusted if necessary. Typically, the optimal dose is 4.6 mg per day. In some cases it may be justified by a slower increase in the dose and lower initial and maintenance doses.

Doses above 10 mg per day showed a higher efficiency compared with lower doses and may cause the appearance of extrapyramidal symptoms. Due to the fact that the safety of doses above 16 mg per day has not been studied, doses above this level can not be applied.

For information on the use for the treatment of schizophrenia in children under 15 years are not available.

Elderly patients. It is recommended initial dose of 0.5 mg twice daily intake. The dosage can be individually increased by 0.5 mg twice per day to 2.1 mg twice a day.

Diseases of the liver and kidneys. Recommended starting dose of 0.5 mg per reception 2 times a day. This dose can be gradually increased to 1 -2 mg per administration twice a day.

Abuse of drugs or drug dependence recommended daily dose – 2-4 mg.

Behavioral disturbances in patients with dementia.
Recommended starting dose of 0.25 mg twice a day technique (use adequate dosage form). If necessary dosage can be individually increased by 0.25 mg 2 times a day, no more than a day. For most patients, the optimal dose is 0.5 mg twice a day. However, some patients are shown receiving 1 mg 2 times a day.

On reaching the optimum dose of the drug can be recommended once daily.

Mania in bipolar disorder
recommended initial dose – 2 mg per day in one step. If necessary, this dose may be increased to 2 mg per day, no more than a day. For most andriol testocaps patients, the optimal dose is 6.2 mg per day.

Conduct disorders in patients with mental retardation

Patients weighing 50 kg or more – recommended initial dose – 0.5 mg once a day. If necessary, this dose may be increased to 0.5 mg per day, no more than a day. For most patients, the optimal dose is 1 mg per day. However, preferred for some patients receiving 0.5 mg per day, whereas some require increasing doses up to 1.5 mg per day.

Patients weighing less than 50 kg – recommended initial dose – 0.25 mg once daily. If necessary, this dose may be increased by 0.25 mg per day, no more than a day. For most patients, the optimal dose is 0.5 mg per day. However, preferred for some patients receiving 0.25 mg per day, whereas some require increasing doses up to 0.75 mg per day.

Long-term use Risdonala adolescents should be carried out under the constant supervision of a physician.

Use in children under 15 years is not recommended.

Side effect On the part of the nervous system: insomnia, agitation, anxiety, headache, sometimes -sonlivost, fatigue, dizziness, impaired concentration, blurred vision, rarely – extrapyramidal symptoms (tremor, rigidity, hypersalivation, bradykinesia, akathisia, acute dystonia) , mania or hypomania, stroke (in elderly patients with predisposing factors), as well as hypervolemia (either due to polydipsia or because the syndrome of inappropriate secretion of antidiuretic hormone), tardive dyskinesia (involuntary rhythmic movements mainly language and / or persons) neuroleptic malignant syndrome (hyperthermia, muscle rigidity, autonomic instability functions, impaired consciousness and increased ), thermoregulation disorders and seizures.

From the digestive system: constipation, dyspepsia, nausea or vomiting, abdominal pain, increased activity of “liver” transaminases, dry mouth, hypo- or hypersalivation, anorexia and / or increased appetite, increased or decreased body weight.

Since the cardiovascular system: sometimes orthostatic hypotension, reflex tachycardia, or increased blood pressure.

From the side of hematopoiesis: neutropenia, thrombocytopenia.

From endocrine system: galactorrhea, gynecomastia, irregular menstruation, amenorrhea, weight gain, hyperglycemia and exacerbation andriol testocaps of preexisting diabetes mellitus.

With the genitourinary system: priapism, erectile dysfunction, abnormal ejaculation, anorgasmia, urinary incontinence.

Allergic reactions: rhinitis, rash, angioedema, photosensitivity.

For the skin: dry skin, hyperpigmentation, itching, seborrhea.

Other: arthralgia.

Symptoms: drowsiness, sedation, depression of consciousness, tachycardia, hypotension, extrapyramidal disorder, in rare cases, prolongation of the interval QT. Treatment: it is necessary to ensure a free airway to ensure adequate oxygenation and ventilation, gastric lavage (after intubation if the patient is unconscious) and the appointment of activated charcoal in combination with laxatives. Symptomatic therapy directed at maintaining vital functions.

For early diagnosis of possible cardiac arrhythmias need to begin ECG monitoring as soon as possible. Careful medical supervision and ECG monitoring is carried out to complete disappearance of symptoms of intoxication. There is no specific antidote.

The interaction with other drugs
Given risperidone has effect primarily on the central nervous system, it should be used with caution in combination with other centrally acting drugs and alcohol.

Risperidone reduces the effectiveness of levodopa or other dopamine agonists. Clozapine decreases clearance of risperidone.

When using carbamazepine marked reduction in the concentration of the active antipsychotic fraction of risperidone in plasma. Similar effects may be observed with other hepatic enzyme inducers.Phenothiazines, tricyclic antidepressants and some of the b-blockers may increase the plasma concentrations of risperidone, but this does not affect the concentration of the active antipsychotic fraction.

Fluoxetine can increase the concentration of risperidone in the plasma, but to a lesser extent the concentration of the active fraction antipsychotic, risperidone dose should therefore be corrected.

In the application of risperidone with other drugs that are highly bound to plasma proteins, clinically pronounced displacement of a drug from the plasma protein fraction is observed.

Antihypertensive medicines increase the severity of blood pressure reduction on the background of risperidone.

special instructions

Transition from other antipsychotic therapy. In schizophrenia, the beginning of treatment with risperidone, we recommend gradually cancel the previous therapy, if clinically justified. If patients are transferred from the depot forms of therapy antipsychotics, risperidone it is recommended to start in place of the next scheduled injection. Periodically assess the need for continued therapy potivoparkinsonicheskimi drugs. In connection with the a-adrenoceptor blocking effect of risperidone, orthostatic hypotension can occur, especially during the initial dose adjustment. In the event of hypotension should consider lowering the dose. In patients with diseases of the cardiovascular system, as well as dehydration, hypovolemia, or cerebrovascular disorders, the dose should be increased gradually, as recommended (see. Dosage and administration).

The occurrence of extrapyramidal symptoms is a risk factor for the development of tardive dyskinesia. In case of signs and symptoms of tardive dyskinesia should consider abolishing all antipsychotics. In the event of a neuroleptic malignant syndrome, characterized by hyperthermia, muscle rigidity, autonomic instability functions, impairment of consciousness, and increased levels of creatine is necessary to cancel all antipsychotic drugs, including risperidone.

In case of cancellation of carbamazepine and other inducers of “liver” enzymes risperidone dose should be reduced.

Patients should be advised to refrain from eating because of the possibility of weight gain.

During treatment should refrain from andriol testocaps activities potentially hazardous activities that require high concentration and psychomotor speed reactions, as well as the intake of alcohol. steroiden kaufen

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