The endocrine system: diabetes, menorrhagia. Hematology: often marked leukopenia, gipogemoglobinemiya, reduction in the number of neutrophils and a high number of eosinophils. Rarely observed leukocytosis, neutrophilia and an increase in prothrombin index. Allergic andriol testocaps bodybuildingreactions: bronchospasm, angioedema, anaphylaxis, Stevens-Johnson syndrome.
Other side effects: hyperlipidaemia, fever, weight loss, changes in laboratory parameters of liver function (increased transaminase levels), hypovolemia (dehydration), vitamin deficiency, cachexia, peripheral edema, glycosuria, gout, hypercholesterolemia, redistribution / accumulation of body fat.
Laboratory parameters: increase of gamma glutamyl transpeptidase activity in plasma (GGT), creatinine phosphokinase (CPK), alkaline phosphatase (ALP), alanintransaminazy, aspartate transaminase, amylase, increased plasma levels of triglycerides, uric acid; hyperglycemia, hyperbilirubinemia, gipermagniemiya, hypokalemia, hypocalcemia, decreased free and total thyroxine (T4) in the blood plasma.
Symptoms: paresthesia, repeated vomiting, diarrhea, dehydration (decreased blood pressure, renal failure), asthenia.
Treatment: gastric lavage and intestinal dialysis with an adsorbent (activated charcoal), followed by ingestion.
INTERACTION WITH OTHER DRUGS effect of other drugs on ritonavir. Drugs that increase the activity of SYR3A, such as phenobarbital, carbamazepine, dexamethasone, phenytoin, rifampin and rifabutin lead to increased clearance of ritonavir, thus, its concentration in the blood plasma decreases. Smoking leads to ritonavir AUC reduction 18%.
. The action of ritonavir on other drugs
It is proved that ritonavir may increase the activity of glucuronosyltransferase, so we had to increase the dosage of drugs biotransformed by the action of this enzyme, due to the reduction of their efficiency by sharing a.
There have been reports of adverse andriol testocaps bodybuilding reactions on the part of the cardiovascular and nervous systems, while the appointment of ritonavir with disopyramide ., mexiletine, nefazodone, or fluoxetine
in patients receiving fluticasone propionate, in the appointment of ritonavir higher doses developed Cushing’s syndrome and showed signs of adrenal suppression. Alprazolam: significantly reduced Cmax of alprazolam (16%) and sedation while admission to ritonavir. There may also be minor psychomotor disturbances. Amprenavir: the concentration increases. Buspirone: primarily metabolized SYR3A4, so its concentration can increase significantly, thereby reducing the dose of buspirone is recommended against its reception with ritonavir.
Almost completely inhibited the formation of 14-hydroxyclarithromycin (the major metabolite of clarithromycin).
Due to the large therapeutic clarithromycin effective range is no need to reduce the dose in patients with normal renal function. For patients with renal insufficiency adjustment should provide the following doses: the creatinine clearance 30 to 60 ml / min clarithromycin dose should be reduced by 50%, with creatinine clearance <30 mL / min clarithromycin dose should be reduced by 75%. Doses of clarithromycin> 1 g / day should not be administered in combination with ritonavir.
Delavirdine: inhibitor SYR3A4-metabolized drugs. Equilibrium increases of ritonavir, 50% and 75%, respectively, thereby requiring dose reduction of ritonavir. In turn, ritonavir has no effect on the pharmacokinetics of delavirdine. Desipramine: ritonavir increases by 145% AUC of desipramine, therefore, should provide a dose reduction of desipramine for patients taking it in combination with ritonavir. Didanosine: Ritonavir lowers equilibrium Cmax and AUC of ddI by 16% and 13% respectively. In order andriol testocaps bodybuilding to avoid the incompatibility of recommended drugs at intervals of not less than 2.5 hours.Disulfiram / metronidazole: in capsules with ritonavir contains 10% ethanol, so avoid co-administration of ritonavir with disulfiram or drugs, disulfiram has similar effects, such as metronidazole. Efavirenz :equilibrium AUC of efavirenz was increased by 21%. Associated with that observed 17% increase in AUC of ritonavir.