Absorption from the gastrointestinal tract – fast (fatty food reduces the rate but not the extent of absorption). Bioavailability – 20%. Andriol for sale Connection with the plasma protein-85%.. Plasma concentration is maintained above the minimum essential concentration for Mycobacterium tuberculosis and 30 hours after administration.
It penetrates into the cells of various organs and tissues. The ratio of intracellular to extracellular concentration – 9 for neutrophils and monocytes to 15.Penetrates through the blood-brain barrier (concentration in cerebrospinal fluid is about 50% of plasma concentrations). The greatest concentration – in the lungs (24 hours after receiving 5-10 times higher than that in plasma). The volume of distribution – 9 l / kg.
It is metabolized in the liver to inactive metabolites.
Pulmonary tuberculosis chronic caused by rifampicin-resistant strains of Mycobacterium tuberculosis (in combination therapy). Infection (localized or disseminated form) caused by Mycobacterium tuberculosis, Mycobacterium avium (including intracellularly located), Mycobacterium xenopi et al. Atypical bacteria (including those in immunocompromised patients with a count of 200 lymphocytes / l or less) – treatment (adjuvant therapy) and prophylaxis (monotherapy).
: Hypersensitivity to rifabutin or other rifamycin history. Due to insufficient clinical experience is not indicated during pregnancy and lactation, as well as children.
Severe renal / hepatic failure.
Overdosing Symptoms: increased andriol for sale side effects. Treatment: gastric lavage, symptomatic therapy, diuretics.
Dosing and Administration
Inside, 1 time a day, regardless of meals. Prevention of infection in immunosuppressed patients – 300 mg / day.
In combination with other drugs: when nontuberculous mycobacterial infection – 450-600 mg / day, up to 6 months from receipt of the negative sowing.
In chronic multidrug-resistant pulmonary tuberculosis – 300-450 mg / day, up to 6 months from receipt of the negative sowing.
When newly diagnosed pulmonary tuberculosis – 150-300 mg / day for 6 months.
If creatinine clearance less than 30 mL / minute dose reduced by 50%. At moderate hepatic dysfunction and / or kidney does not require dose adjustment.
Nausea, vomiting, change in taste (dysgeusia), diarrhea, abdominal pain, increased activity of “liver” enzymes, jaundice.
Leukopenia, thrombocytopenia, anemia.
Allergic reactions: fever, rash, rarely – eosinophilia, bronchospasm, anaphylactic shock, uveitis.
accelerates drug metabolism in the liver (the dosage required to increase). It reduces the concentration of zidovudine in plasma.
It is unlikely the development of clinically significant interactions with ethambutol, theophylline, sulphonamides, pyrazinamide, fluconazole, zalcitabine.
Fluconazole and clarithromycin andriol for sale increase the concentration of drug in plasma (when taken with clarithromycin daily dose reduced to 300 mg).
Heart failure is necessary to pre-compensate. If treatment is necessary to control the functions of the cardiovascular system, the respiratory system, the content of glucose and electrolytes in the blood, blood volume and the amount of urine. In newborns and infants were observed severe hemodynamic effects. PQ interval can extend at plasma concentrations above 30 ng / ml. Do not stop treatment abruptly.
In the period of treatment should periodically monitor the number of white blood cells, platelets in the peripheral blood, the activity of “liver” enzymes.
Increased risk of uveitis in combination with clarithromycin or administration of high doses. With the development of uveitis is a consulting ophthalmologist, the temporary withdrawal of the drug.
May give a reddish-orange urine, skin and secreted fluids. The patients receiving the drug, should not wear contact lenses because of the possibility of their orange color.
The use of rifabutin as a monotherapy for the prevention of disease caused by Mycobacterium avium, in patients with tuberculosis may lead to the development of cross-resistance to rifabutin and rifampicin.
It is advisable to combine andriol for sale with anti-TB drugs, not belonging to the rifamycin group.