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As with other drugs, rispaksol can have side effects, which, however, appears not at all.
Rispaksol is well tolerated.
The following side effects: the part of the central nervous system (CNS): insomnia, agitation, anxiety, headache ; sometimes Рdrowsiness, fatigue, dizziness, impaired concentration, blurred vision; rarely Рextrapyramidal symptoms (including tremor, rigidity, hypersalivation, bradykinesia, akathisia, acute dystonia). Patients with schizophrenia may hypervolemia (or iz-za polydipsia or iz-za syndrome of inappropriate secretion of antidiuretic hormone), tardive dyskinesia (involuntary rhythmic movements mainly language and / or persons), neuroleptic malignant syndrome (hyperthermia, muscle rigidity, autonomic andriol bodybuilding instability functions , impaired consciousness and increasing creatine phosphokinase levels), thermoregulation disorders and seizures. From the digestive system : constipation, dyspepsia, nausea, vomiting, abdominal pain, elevated liver enzymes, dry mouth, hypo- or hypersalivation, anorexia, increased appetite , increase or decrease in body weight. On the part of the cardiovascular system : orthostatic hypotension and reflex tachycardia, increased blood pressure. The therapy described rispaksolom development of strokes, mostly in elderly patients with predisposing factors. On the part of the hemopoietic system : neutropenia, thrombocytopenia.

Endocrine system : possible galactorrhea, gynecomastia, irregular menstruation, amenorrhea; in rare cases – the development of hyperglycemia or worsening of diabetes mellitus. With the genitourinary system : priapism, erectile dysfunction, abnormal ejaculation, anorgasmia, urinary incontinence. Allergic reactions : rhinitis, skin rash, angioedema.Dermatological reactions : dry skin, hyperpigmentation, pruritus , seborrhea, photosensitivity. Other : arthralgia.

 

Overdose Symptoms : drowsiness, sedation, depression of consciousness, tachycardia, hypotension, extrapyramidal disorder, in rare cases, prolongation of the interval QT. Treatment : it is necessary to ensure a free airway to ensure adequate oxygenation and ventilation, gastric lavage (after intubation if the patient is not consciousness), and the appointment of activated charcoal in combination with laxatives. Symptomatic therapy directed at maintaining vital functions of the body. For the early diagnosis of possible cardiac arrhythmias need to begin ECG monitoring as soon as possible. Careful medical supervision and ECG monitoring is carried out to complete disappearance of symptoms of intoxication. There is no specific antidote.

 

INTERACTION WITH OTHER DRUGS DRUG
Given rispaksol that affects primarily the central nervous system, it should be used with caution in combination with other centrally acting drugs and alcohol. Rispaksol andriol bodybuilding reduces the effectiveness of levodopa or other dopamine agonists. Clozapine decreases clearance of risperidone. In an application rispaksola and carbamazepine, a decrease of concentration of the active antipsychotic fraction of risperidone in plasma. The same effects can be observed with other hepatic enzyme inducers. In an application with rispaksolom phenothiazines, tricyclic antidepressants and some beta-blockers may increase risperidone plasma concentrations, but this does not affect the concentration of the active antipsychotic fraction.
In an application with rispaksolom fluoxetine may increase the concentration of risperidone in the plasma, however, to a lesser degree of concentration the active antipsychotic fraction. When using rispaksola together with other drugs that are highly bound to plasma proteins, clinically pronounced displacement of a drug from the plasma protein fraction is observed. Antihypertensive drugs increase the severity of blood pressure reduction in patients receiving rispaksola.

SPECIAL WARNINGS AND PRECAUTIONS transition from other antipsychotic therapy . In schizophrenia, the beginning of treatment with risperidone, we recommend gradually cancel the previous therapy, if clinically justified. If patients are transferred from the depot forms of therapy antipsychotics, risperidone it is recommended to start in place of the next scheduled injection. Periodically evaluate the need for continuing treatment of anti-Parkinsonian drugs. Due to the alpha-adrenoceptor blocking effect of risperidone, orthostatic hypotension can occur, especially during the initial dose adjustment. In the event of hypotension andriol bodybuilding should consider lowering the dose. In patients with diseases of the cardiovascular system, as well as dehydration, hypovolemia, or cerebrovascular disorders, the dose should be increased gradually, as recommended (see. Dosage and administration).

The occurrence of extrapyramidal symptoms is a risk factor for the development of tardive dyskinesia. In case of signs and symptoms of tardive dyskinesia should consider abolishing all antipsychotics. In the event of a neuroleptic malignant syndrome, characterized by hyperthermia, muscle rigidity, instability of the autonomous functions, impaired consciousness and increased levels of creatine is necessary to cancel all antipsychotic drugs, including risperidone. In case of cancellation of carbamazepine and other inducers of “liver” enzymes risperidone dose should be reduced. Should Patients recommend to refrain from eating because of the possibility of weight gain. rispaksola tablets contain lactose. This drug should not be taken in patients with intolerance to sugars, namely with a rare congenital galactose intolerance, lactase deficiency or malabsorption of glucose / galactose.

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